Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Professor of Medicine

University of Colorado Anschutz Medical Campus

Topics of Professional Interest:
  • Immunopathogenesis of HIV-1 infection
  • Lymphoid tissue immune responses in HIV-1 infection
  • Immune reconstitution in HIV-1 infection
  • Primary HIV-1 infection
  • Sex differences in HIV-1 infection
  • HIV-1-related cardiovascular disease
Current Professional Summary:

Dr Connick is Professor of Medicine at The University of Arizona in Tucson, Arizona. She became Chief of the Division of Infectious Diseases in April 2016. A 1988 Harvard Medical School graduate, Dr Connick later completed an internship and internal medicine residency at Columbia Presbyterian Medical Center in New York and an infectious disease fellowship at the University of Colorado. Dr Connick currently is vice chair of the ACTG Women’s Health Inter-Network Scientific Committee. In 2014, she was named to the scientific advisory committee of amfAR, the American Foundation for AIDS Research, and in 2015 she became a Fellow of the Infectious Disease Society of America. In addition, Dr Connick serves on the editorial boards of the Infectious Disease News, Journal of Acquired Immune Deficiency Syndrome, and Journal of the International AIDS Society, and as a reviewer for Lancet, Nature, and several other infectious disease-related journals.

Committees and Organizations:

1994-                           Co-investigator, Adult AIDS Clinical Trials Unit, Denver, CO

2004-                           Chair, Ionizing Radiation and Radioactive Drug Research Committees, Univ CO, Aurora, CO

2006-                           Advisory Board, Women’s Research Initiative on HIV/AIDS, The Well Project, Atlanta, GA

2006-                           Member, International AIDS Society USA

2007-                           Editorial Review Board, Infectious Disease News 

2008-                           Member, Office of AIDS Research advisory committee to identify priorities for the Women and Girls component of the Trans-            NIH Plan for HIV-Related Research 2010, 2011, 2012.

2008-                           Member, American Association of Immunologists

2008-                           Member, Infectious Disease Society of America

2008-                           Medical Director, Boulder Clinical Translational Research Center, Colorado Clinical and Translational Sciences Institute,   

2010-                           Editorial Board, Journal of Acquired Immune Deficiency Syndromes

2011-                           Member, FDA Antiviral Drug Advisory Committee

2012-                           Women’s Health Inter-Network Scientific Committee (ACTG, IMPAACT, HPTN, HVTN)

2012-                           Member, Women’s Interagency HIV Study (WIHS) External Advisory Board

Honors and Awards:

1978                            A.B. magna cum laude, Bryn Mawr College

1985                            Harvard Medical School Student Research Fellowship

1992-1993                   NIH AIDS Training Grant Fellowship

1998-2004                   First Award (R29), United States Public Health Service

2007-2012                   Elected to “Best Doctors in America”

2011                            Excellence in Mentoring/Advising Award, Academy of Medical Educators, UC Denver    

Education:
  • Bryn Mawr College, (Anthropology) magna cum laude, AB (1978)
  • Harvard Medical School, MD (1988)
  • Columbia Presbyterian Hospital, Department of Medicine, Internship and Residency (1988-1991)
  • University of Colorado Health Sciences Center, Division of Infectious Diseases, Clinical and Research Fellow in Medicine (1991-1994)
Selected Publications:

1. Volberding P, Demeter L, Bosch RJ, Aga E, Pettinelli C, Hirsch M, Vogler M, Martinez A, Little S, Connick E and the ACTG 371 Team.  Antiretroviral Therapy in Acute and Recent HIV Infection: A Prospective Multicenter Stratified Trial of Intentionally Interrupted Treatment. AIDS 2009;23:1987-95.  PMCID:  PMC2888600

2. Miura M, Brumme ZL, Brockman MA, Rosato P, Sela J, Brumme CJ, Pereyra F, Kaufmann DE, Trocha A, Block BL, Daar ES, Connick E, Jessen H, Kelleher AD, Rosenberg E, Markowitz M, Schafer K, Vaida F, Iwamoto A, Little S, and Walker BD.  Impaired fitness of acute/early viruses in persons who become HIV controllers.  J Virol 2010; 84:7581-91.62.  PMCID:  PMC2897600

3.  SmithK, ZhengL, BoschR, TenorioA, Napolitano L, SaagM, ConnickE, GrossB, FrancisI, Valdez

H, WangR, MuurahainenN, StockerV, andPollardR, for the AACTG 5174 Protocol Team.  Treatment with

Recombinant GrowthHormone is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in

HIV-Infected Persons on Antiretroviral Therapy:  Results of ACTG A5174.  AIDS Research andHuman

Retroviruses 2010;26:425-32.  PMCID:  PMC2864047

4. Dykes C, Mukherjee LA, Bosch RJ, Connick E, Volberding PA, Demeter LM. Prevalence of primary

resistance at baseline in acutely and recently infected subjects enrolled in AIDS Clinical Trials Group Protocol

371.  J AIDS 2010;55:132-4.  PMCID:  PMC2928582

5. DillonSM, FriedlanderLJ, Rogers LM, Meditz AL, Folkvord JM, Connick E, McCarter MD, Wilson CC.

Blood Myeloid Dendritic Cells from HIV-1-infected Individuals Display a Pro-apoptotic Profile that is Associated

with Levels of Plasma Viremia and T Cell Activation.  J Virol 2011;85:397-409.  PMCID:  PMC3014213

6. MacEneaney OJ, Jeremy Stoner J, Connick E, and DeSouza CA.  Effects of HIV-1 gp120 and protease inhibitors on apoptotic susceptibility of CD34+ hematopoietic progenitor cells.  J AIDS 2011;56:e49-50.  PMCID:  PMC3038106

7.  Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, Connick E, Folkvord J, Gagliardi K, Kassu A, Akkina SR.  Humanized Rag1γc Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes.  PLoS One 2011; 6 (6):e20169.  PMCID:  PMC3114781

8.  Meditz AL, MaWhinney S, Allshouse A, Feser W, Markowitz M, Little S, Hecht R, Daar ES, Collier AC, Margolick J, Kilby JM, RoutyJ, Conway B, Kaldor J, Levy J, Schooley R, Cooper DA, Altfeld M, Richman D, Connick E.  Sex, Race, and Geographic Region Influence Clinical Outcomes Following Primary HIV-1 Infection.  J Infect Dis 2011;203:442-51.   PMCID:  PMC3071223

9.  Connick E, Bosch RJ, Aga E, Schlichtemeier R, Demeter LM, Volberding P and the ACTG 709 Team.  Augmented HIV-specific Interferon-gamma Responses, but Impaired Lymphoproliferation During Interruption of Antiretroviral Treatment Initiated in Primary HIV Infection.  J AIDS 2011;58:1-8.  PMCID: PMC3159837

10.  Meditz AL, Haas MK, Folkvord AJM, Melander K, Young R, McCarter M, MaWhinney S, Campbell T, Lie Y, Coakley E, Levy DN, Connick E.  HLA-DR+CD38+CD4+ T Lymphocytes Have Elevated CCR5 Expression and Produce the Majority of R5-tropic HIV-1 RNA in Vivo.  J Virol 2011;85:10189-10200.  PMCID:  PMC3196402

11.  Vojnov L, Martins MA, Almeida JR, Ende Z, Rakasz EG, Reynolds MR, Leon EJ, Weisgrau KL, Burwitz BJ, Folkvord JM, Veloso de Santana MG, Costa Neves PC, Connick E, Skinner PJ, Gostick E, O'Connor DH, Wilson NA, Bonaldo MC, Galler R, Price DA, Douek DC, Watkins DI.  GagCM9-Specific CD8 T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo.  PLoS One. 2011;6(8):e23515.  PMCID: PMC3162554

12.  HoganC, DeGruttolaV, SunX, Fiscus S, Del RioC, HareB, MarkowitzM, ConnickE,  MacatangayB, TashimaK, FrazierT, DaarE, LittleS, and the A5217 Study Team.  The Setpoint Study – Effect of Immediate Versus Deferred Antiretroviral Therapy on Virologic Setpoint in Recently HIV-1-Infected Individuals:  AIDS Clinical Trials Group A5217.  J Infect Dis 2012;205:87-96.  PMCID:  PMC3242744

13.  Meditz AL, Moreau KL, MaWhinney S, Gozansky WS, Melander K, Kohrt, WM, Wierman, ME, Connick E. CCR5 Expression is Elevated on Endocervical CD4+ T-Cells in Healthy Postmenopausal Women. J AIDS 2012;59:221-8.  PMCID:  PMC3288615

14.  Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch B. CD28-Negative CD4+ and CD8+ T-cells in ART-Naive HIV-Infected Adults Enrolled in ACTG Studies.  J Infect Dis 2012;205:1730-8.  PMCID:  PMC3415854

15.  Brenchley JM, Vinton C, Tabb B, Hao X, Connick E, Pairidini M, Lifson J, Silvestri G, Estes JD.  Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections.  Blood 2012; 120:4172-81.  PMC Journal – In Process