Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Professor of Neurology
Yale University School of Medicine
New Haven, Connecticut

Topics of Professional Interest:

Neuropathogenesis of HIV

HIV-associated neurological and cognitive disorders

Effects of acute and early HIV infection on the CNS

Effects of antiretroviral therapy in the CNS

CNS reservoirs for HIV

 

Current Professional Summary:

Dr. Serena Spudich is a neurologist with an active program of patient-oriented research related to central nervous system HIV. Dr. Spudich’s clinical and translational research focuses on characterization of the central nervous system in HIV-infected patients in an effort to understand and treat the processes underlying damage to the nervous system by HIV, and better understand whether the central nervous system compartment harbours persistent HIV in the setting of antiretroviral therapy.  Her current program employs a multidisciplinary approach to patient-oriented research in neuro-HIV, through active collaborations with researchers in immunology, radiology, neuropsychology, virology, and molecular biomarkers.  She applies these methods to novel studies of patients that may inform about HIV neuropathogenesis and HIV reservoirs and cure, including individuals with acute or early HIV infection and patients at different stages of treatment with antiretroviral therapy.  Her studies focus on subjects recruited in urban centers in the US and other international sites including Bangkok, Thailand. She also cares for individuals living with HIV in at the Nathan Smith HIV Clinic at Yale.

Committees and Organizations:

Panel Member, USA HHS Panel on Antiretroviral Guidelines for Adults and Adolescents

Program Committee Member, Conference on Retroviruses and Opportunistic Infections

Chair Ex-officio, Neurology Collaborative Science Group, AIDS Clinical Trials Group

Previously Investigator-at-large, AIDS Clinical Trials Group (ACTG) HIV Reservoirs and Eradication Transformative Science Group

 

 

Honors and Awards:

2004  Young Investigator Award, 11th Conference on Retroviruses and Opportunistic Infections 

2003  Warren-Whitman Richardson Fellowship, Harvard Medical School 

2002  John P. Utz Fellowship in Medical Mycology, National Foundation for Infectious Diseases

2002  Clinical Investigator Training Program Fellowship, Harvard University/Massachusetts Institute of Technology, Division of Health, Sciences, and Technology

1999  Huesby Award for Teaching, Department of Medicine, University of Washington

Education:

Stanford University, B.A. in Human Biology with Honors in Humanities (1991)

Stanford University, M.A. in Philosophy of Science (1992)

University of California, San Francisco, MD with Thesis (1997)

University of Washington, Seattle, Internal Medicine Resident (1997-99)

Massachusetts General/Brigham and Women’s Hospital (Harvard), Neurology Resident (1999-2002)

Harvard Medical School, Neuro-infectious Disease Fellowship (2003)

University of California, San Francisco, Neuro-AIDS Fellowship (2004)

Selected Publications:

1.   Spudich SS, Huang W, Nilsson AC, Petropoulos CJ, Liegler TJ, Whitcomb JM, Price RW.  HIV-1 Chemokine Coreceptor Utilization in Paired Cerebrospinal Fluid and Plasma Samples:  A Survey of Subjects with Viremia.  Journal of Infectious Diseases, 2005; 191:890-8.

2.   Spudich S, Nilsson A, Liegler T, Petropoulos C, Deeks SG, Paxinos EE, Price RW.  Cerebrospinal Fluid HIV Infection and Pleocytosis: Relation to Systemic Infection and Antiretroviral Treatment.  Biomed Central Infectious Diseases, 2005; 5(98).

3.   Spudich S, Lollo N, Liegler T, Deeks SG, Price RW.  Cerebrospinal Fluid HIV Treatment Benefit in the Setting of Systemic Virological Supression and Failure. Journal of Infectious Diseases. 2006 Dec 15;194(12):1686-96.

4.   Price, RW, Spudich S.  Antiretroviral Therapy and Central Nervous System HIV-1 Infection.  Journal of Infectious Diseases. 197 Suppl 3:S294-306, 2008.

5.   Probasco J, Deeks SG, Lee E, Hoh R, Price RW, Spudich S.  Cerebrospinal Fluid in HIV-1 Systemic Viral Controllers: Absence of HIV-1 RNA and Intrathecal Inflammation.  AIDS, 2010 Apr 24;24(7):1001-5.

6.    Schnell G, Price RW, Swanstrom R, and Spudich S.  Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection.  Journal of Virology, 2009 Dec 16.

7.    Edén A, Fuchs D, Hagberg L, Nilsson S,  Spudich S, Svennerholm B, Price RW,  Gisslén M. HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. Journal of Infectious Diseases, 2010 Dec 15;202(12):1819-25.

8.   Spudich S, GisslenM, HagbergL, LeeE, LieglerT, BrewB, FuchsD, TambussiG, CinqueP, HechtFM, and Price RW.  Central Nervous System Immune Activation Characterizes Primary HIV-1 Infection Even in Subjects with Minimal Cerebrospinal Fluid Viral Burden.  Journal of Infectious Diseases, 2011; 204(5):753-60.

9.   Schnell G, Joseph S, Spudich S, Price RW, and Swanstrom R.  HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types. PloS Pathogens, 2011 Oct;7(10):e1002286.

10.  Valcour V, Chalermchai T, Sailasuta N, Marovich M, Lerdlum S, Suttichom D, Suwanwela N, Jagodzinski L,  Michael N, Spudich S, Griensven F, de Souza M, Kim J, Ananworanich J, RV254/SEARCH 010 Study Group. CNS viral invasion and inflammation during acute HIV.  Journal of Infectious Diseases, 2012 Jul;206(2):275-282.

11.  Peluso M, Ferretti F, Peterson J, Lee E, Fuchs D, Boschini A, Gisslen M, Angoff N, Price RW, Cinque P, and Spudich S. Symptomatic cerebrospinal fluid HIV escape in patients on antiretroviral therapy with suppressed plasma viral load. AIDS, 2012 May 17. [Epub ahead of print].

 

 

Presentations

Advances in the Clinical Management of HIV Disease and Hepatitis C Virus Infection

An Advanced CME Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management