Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Associate Professor of Pharmacy
School of Pharmacy
University of North Carolina at Chapel Hill

Topics of Professional Interest:
  • Antiretroviral pharmacology, including drug penetration into sanctuary sites, drug interactions, drug metabolizing enzymes, drug transporters, and phenotype and genotype correlations
  • HIV pharmacology
  • Pharmacokinetics
  • Understanding and predicting drug-drug interactions
Current Professional Summary:

Dr Kashuba is a clinical pharmacologist and Associate Professor at the University of North Carolina at Chapel Hill (UNC-CH) School of Pharmacy. She is Director of the UNC Center for AIDS Research Clinical Pharmacology and Analytical Chemistry Core, and Director and Pharmacologist for the UNC AIDS Clinical Trials Group Pharmacology Support Laboratory. In addition to her research program, Dr Kashuba teaches drug metabolism, pharmacokinetics, and antiretroviral pharmacology. Her research interests include antiretroviral pharmacokinetic and pharmacodynamic relationships in sanctuary sites, and understanding and predicting drug-drug interactions.

Committees and Organizations:
  • Vice Chair, Pharmacology Committee, Adult AIDS Clinical Trials
    Group (2004-present)
  • Pharmacologist, Adult AIDS Clinical Trials Group (1999-present)
Honors and Awards:
  • Paper of the Year, Society for Infectious Diseases Pharmacists (2005)
  • Hollingsworth Scholar, School of Pharmacy, UNC-CH (2002-2004)
  • Young Investigator of the Year, Society of Infectious Diseases
    Pharmacists (2003)
  • UNC Faculty Scholar, Building Interdisciplinary Research Careers in Women's Health (2000-2002)
Education:
  • University of Toronto, Toronto, Canada, BSc in Pharmacy (1990)
  • Women's College Hospital, Toronto, Canada, Pharmacy Practice
    Residency (1991)
  • State University of New York at Buffalo, Doctor of Pharmacy, (1995)
  • Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, NY, Clinical Pharmacology Fellowship (1997)
Selected Publications:
  1. Rezk NL, Crutchley RD, Kashuba AD. Simultaneous quantification of emtricitabine and tenofovir in human plasma using high-performance liquid chromatography after solid phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;822:201-208.
  2. Kashuba AD, Tierney C, Downey GF, Acosta EP, Vergis EN, Klingman K, Mellors JW, Eshleman SH, Scott TR, Collier AC. Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results. AIDS. 2005;19:145-152.
  3. Min SS, Corbett AH, Rezk N, Cu-Uvin S, Fiscus SA, Petch L, Cohen MS, Kashuba AD. Protease Inhibitor and Nonnucleoside Reverse Transcriptase Inhibitor Concentrations in the Genital Tract of HIV-1-Infected Women. J Acquir Immune Defic Syndr. 2004;37:1577-1580.
  4. Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos. 2004;32:359-363.
  5. Rezk NL, Tidwell RR, Kashuba AD. High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;805:241-247.
  6. Lim ML, Min SS, Eron JJ, Bertz RJ, Robinson M, Gaedigk A, Kashuba AD. Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction. J Acquir Immune Defic Syndr. 2004;36:1034-1040.
  7. Corbett AH, Eron JJ, Fiscus SA, Rezk NL, Kashuba AD. The pharmacokinetics, safety, and initial virologic response of a triple-protease inhibitor salvage regimen containing amprenavir, saquinavir, and ritonavir. J Acquir Immune Defic Syndr. 2004;36:921-928.
  8. Rezk NL, Tidwell RR, Kashuba AD. Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;791:137-147.
  9. McRae MP, Brouwer KLR, Kashuba AD. Cytokine regulation of P-glycoprotein. Drug Metab Rev. 2003;35:19-33.
  10. Reddy YS, Gotzkowsky SK, Eron JJ, Kim JY, Fiske WD, Fiscus SA, Petch L, Cohen MS, Kashuba AD. Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men. J Infect Dis. 2002;186:1339-1343.