Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Director of Hepatology
Vice Chief, Gastroenterology
Massachusetts General Hospital
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts

Topics of Professional Interest:
  • Hepatitis C virus (HCV) pathogenesis
  • HCV/HIV coinfection
  • Hepatitis B virus (HBV)/HIV coinfection
  • Antiviral therapies for HCV, HBV
Current Professional Summary:

Dr Chung is Director of Hepatology, Vice Chief of Gastroenterology, and Program Director of the Advanced Hepatology Fellowship Program at Massachusetts General Hospital. He is also Medical Director of the Liver Transplant Program at Partners HealthCare in Boston. Dr Chung serves as director of the Liver Research Center and the National Institutes for Health (NIH) U19 Center for Human Immunology, which is responsible for elucidating the mechanisms of HCV persistence and pathogenesis.

Committees and Organizations:
  • ACTG Hepatitis Transformative Study Group (Vice Chair)
  • AASLD Basic Research Committee
  • Associate Editor, Journal of Infectious Diseases
  • Associate Editor, Gastroenterology
  • Associate Editor, Therapeutic Advances in Gastroenterology
Honors and Awards:
  • Housestaff Teaching Award, Johns Hopkins University
  • Medical Services Teaching Award, Massachusetts General Hospital
  • Teaching Award, Harvard Medical School
  • Advanced Research Training Award, American Gastroenterological Association
  • Elsevier Research Award, American Gastroenterological Association
Education:
  • Yale, MD
  • Johns Hopkins University, Residency, Internal Medicine
  • Massachusetts General Hospital, GI Fellowship
Selected Publications:
  1. Jang JY, Shao RX, Lin W, Weinberg E, Chung WJ, Tsai WL, Zhao H, Goto K, Zhang L, Mendez-Navarro J, Jilg N, Peng LF, Brockman MA, Chung RT. HIV infection increases HCV-induced hepatocyte apoptosis. J Hepatol. 2011;54:612-620.
  2. Lin W, Wu G, Li S, Weinberg EM, Kumthip K, Peng LF, Méndez-Navarro J, Chen WC, Jilg N, Zhao H, Goto K, Zhang L, Brockman MA, Schuppan D, Chung RT. HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J Biol Chem. 2011;286:2665-2674.
  3. Sherman KE, Rouster SD, Stanford S, Blackard JT, Shire N, Koziel M, Peters M, Chung RT. Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens. J Infect Dis. 2010;201:712-719.
  4. Kim KA, Lin W, Tai AW, Shao RX, Weinberg E, De Sa Borges CB, Bhan AK, Zheng H, Kamegaya Y, Chung RT. Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection. J Hepatol. 2009;50:705-711.
  5. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe. 2009;5:298-307.
  6. Lin W, Weinberg EM, Tai AW, Peng LF, Brockman MA, Kim KA, Kim SS, Borges CB, Shao RX, Chung RT. HIV increases HCV replication in a TGF-beta1-dependent manner. Gastroenterology. 2008;134:803-811.
  7. Blackard JT, Hiasa Y, Smeaton L, Jamieson DJ, Rodriguez I, Mayer KH, Chung RT. Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection. J Infect Dis. 2007;195:1765-1773.
  8. Kim SS, Peng LF, Lin W, Choe WH, Sakamoto N, Kato N, Ikeda M, Schreiber SL, Chung RT. A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication. Gastroenterology. 2007;132:311-320.
  9. Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA Jr, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrob Agents Chemother. 2007;51:3756-3759.
  10. Chung RT, Andersen J, Volberding P, et al. Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons. N Engl J Med. 2004;351:451-459.

Presentations

Management of Hepatitis C Virus in the New Era: Small Molecules Bring Big Changes