Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Director, Program in Nutritional Metabolism
Professor, Harvard Medical School
Boston, Massachusetts

Topics of Professional Interest:
  • The AIDS wasting syndrome
  • Lipid management in the HIV lipodystrophy syndrome
  • HIV lipodystrophy
  • Disorders of insulin and glucose metabolism in HIV
  • Metabolic complications of HIV disease
Current Professional Summary:

Dr Grinspoon is a Clinical Researcher at the Neuroendocrine Unit of Massachusetts General Hospital in Boston, and an Assistant Professor of Medicine at Harvard Medical School.

Committees and Organizations:
Honors and Awards:
  • Editorial Board, Journal of Clinical Endocrinology and Metabolism
  • NIH NCRR & NIDDK Study Sections
  • Health and Human Services Panel on Nutrition Guidelines in HIV
  • Cornell University, BA (1983)
  • University of Rochester School of Medicine, MD (1988)
  • Columbia Presbyterian Hospital, Internal Medicine Residency (1988–1992)
  • Massachusetts General Hospital, Endocrine Fellowship (1992–1995)
Selected Publications:
  1. Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men. J Clin Endocrinol Metab.
  2. Body composition and endocrine function in women with AIDS wasting. J Clin Endocrinol Metab.
  3. Effects of androgen administration in men with AIDS wasting syndrome: a randomized, placebo-controlled trial. Ann Intern Med.
  4. Fasting hyperinsulinemia and changes in regional body composition in HIV-infected women. J Clin Endocrinol Metab.
  5. Fasting hyperinsulinemia in HIV-infected men: relationship to body composition, gonadal function and protease inhibitor use. J Clin Endocrinol Metab.
  6. Metformin use in the HIV lipodystrophy syndrome: a randomized, controlled trial. JAMA.
  7. Metabolic abnormalities and cardiovascular disease risk factors in HIV-infected men and women with the lipodystrophy syndrome. Clin Infect Dis.
  8. Increased PAI-1 and tPA antigen levels are reduced with metformin therapy in HIV-infected patients with fat redistribution and insulin resistance. J Clin Endocrinol Metab.
  9. Assessment of growth hormone dynamics in the HIV lipodystrophy syndrome. J Clin Endocrinol Metab.
  10. Transdermal testosterone administration in women with AIDS wasting: a pilot study. J Clin Endocrinol Metab.


An Advanced CME Live Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management