Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Professor of Medicine, Molecular Biology and Genetics
Director of the MD/PhD Program
The Johns Hopkins University School of Medicine
Baltimore, MD

Topics of Professional Interest:
  • HIV reservoirs
  • Mechanisms of viral persistence in patients on HAART
  • AIDS vaccine development
Current Professional Summary:

Dr Siliciano is a Professor of Medicine and the Director of the MD/PhD Program at Johns Hopkins University School of Medicine.
        

Committees and Organizations:
  • American Association of Immunologists (1987–)
  • American Society for Clinical Investigation (1994–)
Honors and Awards:
  • Merit Award, National Institutes of Health (1993)
  • Section Editor, Journal of Immunology (1994–1998)
  • Chairman, AIDS and Related Research Study Section 1, NIH (1996–1998)
  • Plenary Lecture, 12th World AIDS Conference, Geneva, Switzerland (1998)
Education:
  • Princeton University, AB, Chemistry (1974)
  • Johns Hopkins University School of Medicine, MD, Medicine (1982)
  • Johns Hopkins University School of Medicine, PhD, Immunology (1983)
Selected Publications:
  1. Chun TW, Finzi D, Nelson K, Margolick J, Siliciano RF. In vivo fate of HIV-1 infected T cells: rates of transition to stable latency. Nat Med. 1995;1:1284-1290.
  2. Tobery T, Siliciano RF. Targeting of HIV-1 antigens for rapid intracellular degradation enhances CTL recognition and the induction of de novo CTL responses in vivo following immunization. J Exp Med. 1997;185:909-920.
  3. Chun T-W, Carruth L, Finzi D, Shen X, Digiuseppe JA, Taylor H, Hermankova M, Chadwick K, Margolick J, Quinn TC, Kuo Y-H, Brookmeyer R, Zeiger MA, Barditch-Crovo P, Siliciano RF. Quantitation of latent tissue reservoirs and total body load in HIV-1 infection. Nature. 1997;387:183-188.
  4. Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman D, Siliciano RF. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 1997;278:1295-1300.
  5. Finzi D, Siliciano RF. Viral dynamics in HIV-1 infection. Cell. 1998;93:665-671.
  6. Carruth LM, Greten T, Murray CE, Castro MG, Crone SN, Pavlat W, Schneck JP, Siliciano RF. An algorithm for evaluating human cytolytic T lymphocyte responses to candidate AIDS vaccines. AIDS Res Hum Retroviruses. 1999;15:1021-1034.
  7. Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, Smith K, Lisziewicz J, Lori F, Flexner C, Quinn TC, Chaisson RE, Rosenberg E, Walker B, Gange S, Gallant J, Siliciano RF. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1 even in patients on effective combination therapy. Nat Med. 1999;5:512-517.
  8. Persaud D, Pierson T, Ruff C, Finzi D, Chadwick KR, Margolick JB, Ruff A, Hutton N, Ray S, Siliciano RF. A stable latent reservoir for HIV-1 in resting CD4+ T-lymphocytes in HIV-1-infected children. J Clin Invest. 2000;105:995-1003.
  9. Pierson TC, Hoffman TL, Blankson J, Finzi D, Chadwick K, Margolick J, Buck C, Doms R, Siliciano RF. Characterization of chemokine receptor utilization of latent HIV-1 in resting T lymphocytes. J Virol. 2000;74:7824-7833.
  10. Martinez-Picado J, DePasquale MP, Karsonis N, Hanna G, Wong J, Finzi D, Rosenberg E, Gunthard H, Sutton L, Patroplous C, Hellman N, Walker BD, Siliciano RF, D'Aquilla RT. Selection of resistance in the latent reservoir of human immunodeficiency virus type 1 during successful therapy. Proc Natl Acad Sci USA. 2000;97:10948-10953.

Presentations

Improving the Management of HIV Disease®: An Advanced CME Live Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management

15th Ryan White HIV/AIDS AETC Program Clinical CARE Conference: Moving Forward with CARE: Focusing on Passion, Purpose, and Excellence

An Advanced CME Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management

14th Annual Clinical Conference for the Ryan White HIV/AIDS Program