Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Associate Professor of Medicine
Harvard Medical School
Assistant Physician
Massachusetts General Hospital
Director, Viral Hepatitis Clinic
Division of Infectious Diseases
Massachusetts General Hospital
Boston, Massachusetts

Topics of Professional Interest:

Hepatitis C, HIV-1/HCV Coinfection, Acute HCV, Post-Transplant HCV, HCV in Injection Drug Users

Current Professional Summary:

The ultimate goal of my past training and current efforts is to engage the difficult clinical problem of HCV infection, particularly in special populations. Special populations include those with HIV-1/HCV coinfection, acute HCV, and HCV in the prison population. The overall focus of my research is on HCV and HIV translational research at the Division of Infectious Diseases at Massachusetts General Hospital, including multiple projects in immunogenetics and immunology of HCV infection and acute HCV in Massachusetts both in the community and in the prison population. I direct the Viral Hepatitis Clinic in the Division of Infectious Diseases at the Massachusetts General Hospital and am actively involved in the care and treatment of those living with HBV and HCV. I am especially fortunate to have given multiple talks on local, regional, national and international levels to help educate my peers.

Committees and Organizations:
  • Member, AIDS Clinical Trial Group, Hepatitis Transformative Science Group
  • HCV Subcommittee, DHHS Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents
  • PCPI Workgroup for the American Medical Association
  • HCV Workgroup for the American Gastroenterological Association
Honors and Awards:

Maxwell Finland Award for Research Excellence, Massachusetts Infectious Disease Society

Fellow, Infectious Disease Society of America

Education:

Yale University, B.S. 1993

Harvard Medical School, M.D. 1997

Selected Publications:
  1. Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BD. The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T cell count in HIV-1 coinfected individuals. Blood. 2005; Feb 1:105(3): 1170-8. PMID:15459014.
  2. Kim AY, Schulze zur Wiesch J, Kuntzen T, Timm J, Kaufmann DE, Duncan JE, Jones AM, Wurcel AG, Davis BT, Gandhi RT, Robbins GK, Allen TM, Chung RT, Lauer GM, Walker BD. Impaired HCV-specific T cell responses and recurrent HCV in HIV coinfection. PLoS Med 2006 Dec;3(12):e492. PMC1705826.
  3. Kim AY, Timm J, Nolan BE, Reyor LL, Kane K, Berical AC, Zachary KC, Lauer GM, Kuntzen T, Allen TM. Temporal dynamics of a predominant protease-inhibitor resistance mutation in a treatment naïve HCV-infected individual. Journal of Infectious Diseases. 2009;199(5):737-41. PMC2653266 4.
  4. Chen TY, Ding EL, Seage GR, Kim AY. Meta-analysis: increased mortality associated with HCV in HIV-infected persons is not related to HIV disease progression. Clinical Infectious Diseases. 2009;49(10):1605-15. PMC2805261.
  5. Kim AY and Chung RT. Coinfection with HIV-1 and HCV – a one-two punch. Gastroenterology 2009;137(3):795-814.
  6. Mcgovern BH, Nagami EH, Birch CE, Bowen MJ, Reyor LL, Chung RT, Kim AY. Rate of sustained virologic response in relation to baseline hepatitis C virus (HCV) RNA level and rapid virologic clearance in persons with acute HCV infection. Journal of Infectious Diseases. 2009;200(6):877-81. PMC2762747 7.
  7. Mcgovern BH, Birch CE, Bowen MJ, Reyor LL, Nagami EH, Chung RT, Kim AY. Improving the diagnosis of acute hepatitis C infection using expanded viral load criteria. Clinical Infectious Diseases. 2009;49(7):1051-60. PMC2741541.
  8. Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, Lauer GM. Spontaneous control of HCV is associated with the expression of HLA-B*57 and preservation of targeted epitopes. Gastroenterology 2011; 140(2):686-696. PMC3021586 9.
  9. Schulze zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, Reyor LL, Allen TM, Lohse AW, McGovern B, Chung RT, Kwok WW, Kim AY, Lauer GM. Broadly directed CD4+ responses are primed during acute HCV infection, but rapidly disappear from the blood with viral persistence. J Exp Med 2012;209(1):61-75. 5.
  10. Kim AY, Nagami EH, Birch CE, Bowen MJ, Lauer GM, McGovern BH. A simple strategy to identify acute HCV infection among newly incarcerated injection drug users. Hepatology 2013;57(3):944-52. PMID:23111904.

Presentations

Management of Hepatitis C Virus in the New Era: Small Molecules Bring Big Changes

An Advanced CME Live Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management

Hepatitis C Virus Infection: Looking Beyond the Interferon Alfa Era

Hepatitis C Virus (HCV) Infection: Looking Beyond the Interferon Alfa Era