Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Professor of Immunology/Microbiology and Medicine
Rush Medical College
Rush-Presbyterian-Saint Luke's Medical Center
Chicago, IL

Topics of Professional Interest:
  • Role of the thymus in HIV pathogenesis
  • Role of induction of CD4 antigen on CD8 cells in HIV disease
  • Role of HIV-specific immunity in maternal-fetal HIV transmission
  • Mucosal immune responses in HCV-infected women
  • Therapeutic immunization and its role in HIV immune-based therapy
  • Innate immunity in HIV pathogenesis and immune therapy
  • Microbicides for HIV
  • Acute HIV disease immunopathogenesis
  • Diagnostics for resource-poor settings
  • Immune reconstitution with HAART
  • Immune-based therapy in HIV disease
  • Immunopathogens of maternal fetal HIV disease
  • Mucosal immune response in heterosexual HIV transmission
Current Professional Summary:

Dr Landay is a Professor and Associate Chairman of the Department of Immunology/Microbiology and a Professor of Medicine, Rush Medical College. Dr Landay teaches courses in immunology for medical and graduate students. His major research interests are in immunopathogenesis, immune reconstitution, and immune based therapy for HIV disease.

Committees and Organizations:
  • Chair, OAR AIDS Pathogenesis Committee
  • Member, AmFar Review Panel
  • Member, NIH Vaccine Study Section
  • Member, Immune Based Therapy Committee ACTG
Honors and Awards:
  • Visiting Professor, University of Puerto Rico
  • Visiting Professor, University of Southern California
  • Visiting Professor, Emory University
  • Visiting Professor, University New South Wales, Sydney, Australia
Education:
  • Pennsylvania State University, BS (1976)
  • University of Pittsburgh, PhD (1981)
  • University of Alabama, Birmingham, Postdoctoral Fellow
Selected Publications:
  1. Tenorio AR, Smith KY, Kuritzkes D, Young R, Bremer J, Wrin T, Pepropoulous C, Shott S, Landay A, Kessler HA. HIV-1 infected antiretroviral-treated patients with prolonged partial viral suppression: Clinical, virologic and immunologic course. JAIDS. 2003;34(5):491-496.
  2. Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson MA, Merigan TC, Jr., Glesby MJ, and the National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma HIV RNA and CD4 lymphocyte counts in patients with uncontrolled HIV infection. J Infec Dis.2003;188:1804-1814.
  3. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinksy SM, Zack JA. A sound rationale needed for phase III HIV-1 vaccine trials. Science.2004;303(5656):316.
  4. Al-Harthi L, Voris J, Patterson BK, Becker S, eron J, Smith KY, Mildvan D, D'Amico R, Snidow J, Pobiner B, Yau L, Landay A. Evaluation of immune reconstitution parameters in antiretroviral-naive patients: Role of the thymus in immune recovery. HIV Medicine. 2004;5(1):55-65.
  5. Lange CG, Xu Z, Patterson BK, Medvik K, Harnisch B, Asaad R, Valdez H, Lee SJ, Landay A, Lieberman J, Lederman MM. Proliferation responses to HIV p24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS.2004;18(4):605-613.
  6. Mildvan D, Bosch R, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A. Immunophenotypic markers and antiretroviral therapy (IMART): T-cell activation and maturation help predict treatment response. J Infec Dis. 2004;189(10):1811-1820.
  7. Winchester R, Pitt J, Magder LS, Goring HH, Landay A. Mother-to-child transmission of HIV-1: Strong association with certain maternal HLA-B alleles independent of viral load implicates innane immune mechanisms. J Acquir Immune Defic Syndr. 2004;36(2):659-670.
  8. Bahbouhi B, Landay A, and Al-Harthi L. Dynamics of cytokine expression within HIV productively infected primary CD4+ T cells. Blood. 2004;103(12):4581-4587.
  9. Lurain NS, Robert ES, Xu J, Camarca M, Landay A, Kovacs AA, Reichelderfer PS. Human immunodeficiency virus type 1 and cytomegalovirus co-infection in the female genital tract. J Infec Dis. 2004;190(3):619-623.
  10. Smith K, Aga E, Bosch RJ, Valdez H, Connick E, Landay A, Kuritzkes D, Gross BH, Francis IR, McCune JM, Kessler H, Lederman M. Long-term changes in circulating CD4 T lymphocytes in virologically supressed patients after 6 years of highly active antiretroviral therapy. AIDS. 2004;18(14):1953-1956.

Presentations

An Advanced CME Live Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management