Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Professor of Laboratory Medicine, Medicine and Stomatology
Director, General Clinical Research Center
University of California San Francisco
San Francisco, CA

Topics of Professional Interest:
  • Human papillomaviruses
  • Anogenital cancer
  • HIV-HPV molecular interactions
Current Professional Summary:

Dr Palefsky's research interests include the molecular biology and pathogenesis of HPV-associated anogenital neoplasia in the HIV-seropositive host. He is the Program Director of the UCSF/Moffett General Clinical Research Center.
        

Committees and Organizations:
  • AIDS Malignancy Consortium (1999–)
  • Infectious Diseases Society of America
  • Chair, AIDS Malignancy Consortium HPV Working Group (1999–)
Education:
  • McGill University, MD (1980)
  • McGill University, Residency in Medicine (1980–1984)
  • Stanford University, Fellowship in Infectious Diseases (1985–1989)
Selected Publications:
  1. Turner MA, Palefsky JM. Epithelial:stromal interactions modulating penetration of HPV 16-transfected keratinocytes through matrigel membranes. J Invest Dermatol. 1997;109:619-625.
  2. Palefsy JM, Holly EA, Ralston ML, Jay N. Prevalence and risk factors for human papillomavirus infection of the anal canal in HIV-positive and HIV-negative homosexual men. J Acquir Immun Defic Syndr. 1998;177:361-367.
  3. Palefsky JM, Holly EA, Ralston ML, Arthur SP, Jay N, Berry JM, DaCosta MM, Botts R, Darragh TM. Anal squamous intraepithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J Acquir Immun Defic Syndr. 1998;17:320-326.
  4. Palefsky JM, Holly EA, Ralston ML, Jay N, Berry JM, Darragh TM. High incidence of anal high-grade squamous intraepithelial lesions among HIV-positive and HIV-negative homosexual/bisexual men. AIDS. 1998;12:495-503.
  5. Palefsky JM, Minkoff H, Kalish LA, Levine A, Sacks HS, Garcia P, Young M, Melnick S, Miotti P, Burk R. Cervicovaginal human papillomavirus infection in HIV-positive and high risk HIV-negative women. J Natl Cancer Inst. 1999;91:226-235.
  6. Goldie SJ, Kuntz KM, Weinstein MC, Freedberg KA, Welton ML, Palefsky JM. The clinical-effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA. 1999;281:1822-2829.
  7. Lagenaur L, Palefsky JM. Regulation of EBV promoters in oral epithelial cells and lymphocytes. J Virol. 1999;73:6566-6572.
  8. Godie SJ, Kuntz KM, Weinstein MC, Freedberg KA, Palefsky JM. The clinical benefits and cost-effectiveness of screening for anal squamous intraepithelial lesions and anal squamous cell cancer in homosexual and bisexual men. Am J Med. 2000;108:634-641.
  9. Palefsky JM, Holly EA, Ralston ML, Da Costa M, Greenblatt RM. Prevalence and risk factors for anal HPV infection in HIV-positive and high-risk HIV-negative women. J Infec Dis. In press.
  10. Haga T, Kim SH, Jensen RH, Darragh T, Palefsky JM. Detection of genetic changes in anal intraepithelial neoplasia (AIN) of human immunodeficiency virus (HIV)-positive and HIV-negative men. J Acquir Immune Defic Syndr. In press.