Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Chief, Viral Genetics section,
US Military HIV Research Program (MHRP); Henry M. Jackson Foundation (HJF)
Walter Reed Army Institute of Research (WRAIR)
Silver Spring, MD

Topics of Professional Interest:

HIV evolution
HIV vaccine design
HIV acute infection
HIV fitness

Current Professional Summary:

Dr Rolland is chief of the viral genetics section at the US Military HIV Research Program (MHRP) in Silver spring, MD. She obtained her PhD from the University of Bordeaux, France in 2003. Dr Rolland was a post-doctoral fellow in the Microbiology department of the University of Washington, Seattle between 2004 and 2010. She serves as a young investigator on the editorial board of AIDS Research and Human Retroviruses.

Dr Rolland has been involved in HIV vaccine-related research. Her research work is centered on the interplay between HIV-1 genetics and the host immune pressure, principally focusing on HIV-1 vaccine design and the analysis of HIV-1 evolution during acute/early infection, including the study of HIV-1 breakthrough infections in the HIV vaccine efficacy trials.

Committees and Organizations:

Member, Young and Early Career Investigators (YECI) Committee of the HIV Global Enterprise

Honors and Awards:

Mathilde Krim fellowship, amfAR (2008)

Education:

MS in Biochemistry, 1998. University of Rennes 1, France.
D.E.A. in Endocrinology, 1999. University of Montpellier 1, France.
Ph.D. in Biology, 2003. University of Bordeaux 2, France.

Selected Publications:

• Rolland M., Edlefsen PT., Larsen BB., Tovanabutra S., Sanders-Buell E., Hertz T., DeCamp AC., Carrico C., Menis S., Magaret CA., Ahmed H., Juraska M., Chen L., Konopa P., Nariya S., Stoddard JN., Wong K., Zhao H., Deng W., Maust BS., Bose M., Howell S., Bates A., Lazzaro M., O'Sullivan A., Lei E., Bradfield A., Ibitamuno G., Assawadarachai V., O'Connell RJ., DeSouza MS., Nitayaphan S., Rerks-Ngarm S., Robb ML., McLellan JS., Georgiev I., Kwong PD., Carlson JM., Michael NL., Schief WR., Gilbert PB., Mullins JI., Kim JH. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2. Nature. 2012 Sep 10. doi: 10.1038/nature11519.
• Rolland M. and Gilbert P. Evaluating immune correlates in HIV-1 vaccine efficacy trials: what RV144 may provide. AIDS Research and human retroviruses. 2012 Apr;28(4):400-4. epub 27 September 2011.
• Herbeck J.T., Rolland M., Liu Y., McLaughlin S., McNevin J., Zhao H., Wong K., Stoddard J.N., Raugi D.N., Sorensen S., Genowati I., Birditt B., McKay A., Diem K., Maust B.S., Deng W., Collier A.C., Stekler J.D., McElrath M.J., and Mullins J.I. Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processes. 2011. Journal of Virology, Aug;85(15):7523-34.
• Rolland M., Tovanabutra S., deCamp A.C., Frahm N., Gilbert P.B., Sanders-Buell E., Heath L., Magaret C., Bose M., Bradfield A., O’Sullivan A., Crossler J., Jones T., Nau M., Wong K., Zhao H., Raugi D.N., Sorensen S., Stoddard J.N., Maust B.S., Deng W., Hural J., Dubey S., Michael N.L., Shiver J., Corey L., Li F., Self S.G., Kim J., Buchbinder S., Casimiro D.R., Robertson M.L., Duerr A., McElrath M.J., McCutchan F.E., and Mullins J.I. Genetic impact of vaccination on breakthrough HIV-1 sequences from the Step trial. 2011. Nature Medicine. Mar;17(3):366-71. *contributed equally.
• Rolland M., Nickle D.C., Mullins J.I. HIV-1 group M Conserved Elements vaccine. 2007. PLoS Pathogens. Nov;3(11):e157.
• Rolland M., Brander C., Nickle D.C., Herbeck J.T., Gottlieb G.S., Campbell M.S., Maust B.S., Mullins J.I. HIV-1 over time: fitness loss or robustness gain? 2007. Nature Reviews Microbiology. 5(9)1-2.
• Rolland M., Jensen M.A., Nickle D.C., Learn G.H., Heath L., Mullins J.I.. Reconstruction and function of Ancestral Center-of-Tree COT HIV-1 antigens. 2007. Journal of Virology. 81(16):8507-14.
• Nickle D.C., Rolland M., Jensen M.A., Pond S.K., Deng W., Seligman M., Heckerman D.H., Mullins J.I., Jojic N..Coping with viral diversity in HIV vaccine design. 2007. PLoS Computational Biology. Apr 27;3(4):e75.

Presentations

An Advanced CME Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management