Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Director and Senior Investigator

Nick and Sue Hellman Distinguished Professor of Translational Medicine

Gladstone Institute of Virology and Immunology

Professor of Medicine, Microbiology and Immunology

University of California, San Francisco

Topics of Professional Interest:
  • HIV pathogenesis with a specific focus on CD4 T-cell depletion involving abortive infection, inflammasome assembly and induction of pyroptosis
  • Understanding the molecular basis of HIV latency and identifying novel targets for development of an HIV cure
  • HIV transmission including the role of specific viral and host factors
Current Professional Summary:

The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 366 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. Dr. Greene is a member of the Institute of Medicine of the National Academies and a fellow of the American Academy for the Advancement of Science. He also serves as Co-Director of the UCSF-GIVI Center for AIDS Research, and has served as a councilor and president of the Association of American Physicians. In 2013, Dr. Greene became the executive chairman of the Accordia Global Health Foundation, whose mission is to overcome the burden of infectious diseases by building healthcare capacity and strengthening academic medical institutions in Africa.

Committees and Organizations:
  • Co-Director, UCSF-GIVI Center for AIDS Research (CFAR)
  • Executive Chairman, Accordia Global Health Foundation (2013-present), President (2007-2013)
  • Center Director, Global Virus Network (2011-present)
  • Member, Scientific Advisory Board, CFAR University of Alabama, Birmingham (2002-present)
  • Executive Committee, Scientific Advisory Board, Institute of Human Virology (1999-present)
  • Member: AFCR, AAI, ACP, ASCI, AAP, ASM, ASCB, AAAS
Honors and Awards:
  • Member, American Academy of Arts & Sciences (2014)
  • President, Association of American Physicians (2013)
  • Institute of Medicine of the National Academies (2005)
  • Fellow, American Association for the Advancement of Science (2004)
  • Original Member, ISI Highly Cited Researchers (2001)
Education:
  • Stanford University, BA (1971)
  • Washington University School of Medicine, MD, PhD (1971-1977)
  • Massachusetts General Hospital, Internship and Residency (1977-1979)
Selected Publications:
  1. Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC. HIV-1 Nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell. Nature 410:834–838, 2001.
  2. Chen L-f, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-κB action regulated by reversible acetylation. Science 293:1653–1657, 2001.
  3. de Noronha CMC, Sherman MP, Lin HW, Cavrois M, Moir RD, Goldman RD, Greene WC. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294:1105–1108, 2001.
  4. Cavrois M, de Noronha C, Greene WC. A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nat. Biotech. 20:1151–1154, 2002.
  5. Stopak K, de Noronha C, Yonemoto W, Greene WC. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol. Cell. 12:591–601, 2003.
  6. Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC. High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. Proc. Natl. Acad. Sci. USA. 103:15588–15593, 2006. PMCID: PMC1592537
  7. Williams SA, Chen L-f, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC. NF-κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 25:139–149, 2006. PMCID: PMC1356344
  8. Soros VB, Yonemoto W, Greene WC. Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H. PLoS Path. 3:e15, 2007. PMCID: PMC1796622
  9. Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WC. APOBEC3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343–1346, 2008. PMCID: PMC2701658
  10. Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J. Virol. 83:73–80, 2009. PMCID: PMC2612336
  11. Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC. The aminoquinoline surfen inhibits action of semen-derived enhancer of viral infection (SEVI). J. Biol. Chem. 285:1861–1869, 2010. PMCID: PMC2804344
  12. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbler AM, Greene WC. Abortive HIV infection mediates CD4 T-cell depletion and inflammation in human lymphoid tissue. Cell 143:789–801, 2010. PMCID: PMC3026834
  13. Wissing S, Montano M, Garcia-Perez JL, Moran JV, Greene WC. Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells. J. Biol. Chem 286:26427–26437 2011. PMCID: PMC3196128
  14. Lassen KG, Hebbeler AM, Bhattacharyya D, Lobritz MA, Greene WC. A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs. PLoS One 7:e30176, 2012. PMCID: PMC3265466
  15. Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel C, Walther P, Dong M, Witkowska E, Kirchhoff F, Münch F, Greene WC. Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe 10:541–550, 2011. PMCID: PMC3257029
  16. Doitsh G, Galloway NLK, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 505:509-514, 2014. PMCID: PMC4047036
  17. Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 343:428-432, 2014. PMCID: PMC3976200

Presentations

Improving the Management of HIV Disease®: An Advanced CME Live Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management

An Advanced CME Live Course in HIV Pathogenesis, Antiretrovirals, and Other Selected Issues in HIV Disease Management